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Dimitris Papadopoulos: biodecision and onepass: caliber-flex-1b, compared on what they decide, where they run, what they cost and what their publishers report.
| Property | lighteternal/biodecision | onepass/caliber-flex-1b |
|---|---|---|
| Summary | A 4B biomedical decision model by Dimitris Papadopoulos: Qwen3.5-4B tuned with Together AI's Tev1 recipe on 1.75M pharma, clinical-trial and literature decisions. One forward pass gives a temperature-scaled probability per option. Research use only. | Caliber Flex 1B by OnePass. Decision-only model, exactly 1,000,000,000 parameters. |
| Decides | choice, score, noul, classify | choice, noul, score |
| Architecture | biodecision | llm |
| Fine-tuned from | qwen/qwen3.5-4b | qwen/qwen3.5-0.8b-base |
| License | Research use only (several training sources are non-commercial); not validated for patient care | caliber-flex-non-commercial-1.0 |
| Availability | Open weights | Open weights |
| Hosted by | — | — |
| Input price | — | — |
| Decision accuracy | 75.3% | — |
| Calibration error | — | — |
| Valid action rate | — | — |
| Median latency | 39 ms | — |
| p95 latency | — | — |
| Evaluation suite | BioDecision v2 held-out test set (63,432 overlap-screened decisions from public biomedical benchmarks; the maker's own split) | — |
| Latest version | 2.0.0 | 0.3.0 |
| Variants | LICENSE | LICENSE, Modelfile, merged |
| Size of latest version | 8.7 GB | 2.6 GB |
| Files | 15 | 12 |
| Downloads | 0 | 68 |
| Stars | 0 | 0 |
| Tags | system-one, qwen, biomedical, clinical-trials, jev-inspired, research-only, 4b | decision-model, calibrated, qwen3_5, timesfm-distilled, onepass, gguf |
| Updated | Oct 7, 2026 | Oct 29, 2026 |
Figures are from each model’s manifest; accuracy and latency are what the publishers report, on their own suites and hardware. Add a third model.
biodecision is from Dimitris Papadopoulos and caliber-flex-1b from onepass. Both have open weights you can download and run. Both answer choice, score and noul questions. Only biodecision answers classify.
Only biodecision publishes an accuracy figure (75.3% on BioDecision v2 held-out test set (63,432 overlap-screened decisions from public biomedical benchmarks; the maker's own split)); caliber-flex-1b does not, so there is no comparison to make without your own test.
biodecision: Free (open weights). caliber-flex-1b: Free (open weights). Open weights cost nothing per call beyond your own hardware.
Yes, both: systemone pull lighteternal/biodecision and systemone pull onepass/caliber-flex-1b download the weights.